In France, at least 17 million people suffer from allergic diseases. But as surprising as it may seem, the inflammatory mechanisms underlying some respiratory diseases, such as asthma or hay fever, are still poorly understood.
A team of French researchers is opening up new possibilities in understanding these pathologies. In fact, they identified one of the molecules responsible for triggering the allergic reaction.
New treatments
” This alarmin family molecule, called TL1A, is released by lung epithelial cells within minutes of exposure to a mold-type allergen. “, the authors explain.
This pulmonary epithelium is actually a carpet of cells that makes up the inner surface of the lungs. There, this newly discovered molecule interacts with another alarmin, interleukin 33, to alert the immune system to the presence of an allergen.
This double alarm then stimulates immune cell activity, which sets off a cascade of chain reactions responsible for allergic inflammation.
” Thus, alarmins represent therapeutic targets of great interest for the treatment of allergic respiratory diseases. “” the researchers conclude. “Within a few years, treatments based on antibodies that block the alarmin TL1A may benefit patients suffering from severe asthma or other allergic diseases.. »
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