Bovilis Cryptium, a global innovation against cryptosporidiosis

Goals : ” limit clinical manifestations in calves affected by cryptosporidiosis and help limit the use of antibiotics “. Thus, the MSD Santé Animale laboratory launches the Bovilis Cryptium vaccine:” global innovation “, in the form of an injection emulsion, for cattle, administered subcutaneously.

Maternal vaccination; transmission through colostrum
She allows” active immunization of pregnant heifers and cows to produce antibodies against Cryptosporidium parvum glycoprotein 40 (gp40) in their colostrum. “This vaccine is therefore intended to passively immunize calves with colostrum and transition milk to reduce clinical signs (eg, diarrhea) caused by C. parvum.” The gp40 antigens present in Bovilis Cryptium induce the production of antibodies capable of neutralizing C. parvum at different stages of the parasitic cycle. Efficacy has been demonstrated at the sporozoite, trophozoite, meront and merozoite stages. “.
By reducing the severity of clinical signs, “ this solution reduces the use of antibiotics currently used to treat calves severely affected by cryptosporidiosis within a few days, leading to risks of errors, underdosing, resistance and ultimately deterioration of the gut microbiome. “.

Injection 3 weeks before calving; annual reminder
The injection dose is 2 ml subcutaneously. During the first year, two injections are required, 4 or 5 weeks apart, in the third trimester of pregnancy. “ It is very important to complete the primary vaccination at least 3 weeks before calving. “. In subsequent years, revaccination will be carried out once in the third trimester of pregnancy. “at least 3 weeks before calving “.
The effectiveness of Bovilis Cryptium depends, as with any vaccine given to mothers at the end of pregnancy, on correct practices in the collection and distribution of colostrum: ” Colostrum must be given early enough and in sufficient quantities. Transition milk from the vaccinated mother must then be distributed during the first five days of the calf’s life. “.
MSD Santé Animale indicates that Bovilis Cryptium can be administered together with Bovilis Rotavec Corona on the same day at two different injection sites. ” This clarification, mentioned in the SPC, helps to facilitate the implementation of vaccination projects and represents an undeniable time saving for breeders. “In summary, these two combination vaccines provide protection against all five major primary pathogens of neonatal diarrhea in young calves: C. parvum, rotavirus, coronavirus, E. coli F5 and E. coli F41.

Stable up to 28 days after opening.
Bovilis Cryptium can be stored at positive temperatures (< 8°C). up to 28 days after the first puncture of the bottle”. This makes it the second vaccine in the Bovilis range to offer benefits. extension of shelf life after opening from 8 hours to 28 days “This property attracts users” greater flexibility “, in the implementation of vaccine projects. And this contributes” it is better to use different vials without wasting doses in the last batches of vaccination “.
Bovilis Cryptium will be available in 1, 5, 20 and 50 doses. ” All presentations will be gradually replaced by clear PET (polyethylene terephthalate) bottles for greater impact resistance. “.